Bifidobacteria reduce depression

Posted by Trotter on December 27, 2012, at 14:02:57

In reply to Re: High fat diet -) inflammation -) depression » larryhoover, posted by SLS on December 27, 2012, at 12:35:07

This may sound a bit odd, but my current thinking is that most depression is caused by low bifidobacteria in the bowel. Known factors that impact on depression seem to reduce bifidobacteria. For example it is known that stress reduces bifidobacteria. So does a high fat diet. Both are linked to depression.
Why would low bifodobacteria cause depression? Well it seems bifidobacteria are critical in preventing endotoxemia. Endotoxemia causes the release of pro-inflammatory cytokines (PIC) which cross the blood:brain barrier causing depression. While it is not known exactly how bifidobacteria prevent endotoxemia, or how PIC cause depression, there is strong evidence showing that they do.
So, is the cure for depression simply to increase bifidobacteria in the bowel? Well, without well designed human trials this in unknown. However in the only trial I am aware of that looked at increasing bifidobacteria in depressed rats, the results were positive. In mice, increasing bifidobacteria was shown to reduce anxiety.

Thread

High fat diet -) inflammation -) depression Trotter 12/19/12
...
Re: B. infantis reduces inflammation + depression » Trotter SLS 12/23/12
Re: B. infantis reduces inflammation + depression » SLS Trotter 12/23/12
Re: High fat diet -) inflammation -) depression larryhoover 12/25/12
Re: High fat diet -) inflammation -) depression larryhoover 12/25/12
Re: High fat diet -) inflammation -) depression larryhoover 12/25/12
Re: High fat diet -) inflammation -) depression » larryhoover Trotter 12/26/12
Re: High fat diet -) inflammation -) depression rca 12/26/12
Re: High fat diet -) inflammation -) depression » larryhoover Emme_V2 12/26/12
Re: High fat diet -) inflammation -) depression larryhoover 12/27/12
Re: High fat diet -) inflammation -) depression » Trotter larryhoover 12/27/12
Re: High fat diet -) inflammation -) depression rca 12/27/12
Re: High fat diet -) inflammation -) depression » larryhoover SLS 12/27/12
Bifidobacteria reduce depression Trotter 12/27/12
Re: High fat diet -) inflammation -) depression » rca larryhoover 12/27/12
Re: High fat diet -) inflammation -) depression » SLS larryhoover 12/27/12
Re: Bifidobacteria reduce depression » Trotter larryhoover 12/27/12
Re: Bifidobacteria reduce depression Trotter 12/27/12
Re: Bifidobacteria reduce depression » Trotter larryhoover 12/27/12
Re: Bifidobacteria reduce depression Trotter 12/27/12
Re: Bifidobacteria reduce depression Trotter 12/27/12
Re: Bifidobacteria reduce depression » Trotter larryhoover 12/27/12
Re: Bifidobacteria reduce depression » larryhoover Trotter 12/27/12
Re: Bifidobacteria reduce depression Trotter 12/27/12
Re: Bifidobacteria reduce depression » Trotter larryhoover 12/27/12
Re: Bifidobacteria reduce depression » larryhoover Trotter 12/27/12
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Re: Bifidobacteria reduce depression (nm) » Trotter Rosscoe 4/1/15

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poster:Trotter thread:1033371
URL: http://www.dr-bob.org/babble/20121217/msgs/1033981.html