Posted by SLS on December 25, 2012, at 5:37:58
In reply to Re: repost, posted by rjlockhart37 on December 24, 2012, at 20:35:51
> no what I ment, the medications that would help getting off klono depakote, tegretol, trileptal, lamictal....GABA agonists
Those are all reasonable choices theoretically. Where did you find information regarding GABA agonists? What about Gabitril? The other drugs you mentioned are sodium channel inhibitors that reduce glutamatergic transmission. Depakote additionally inhibits GABA transaminase. I thought this property would make it an effective drug to aid in BZD withdrawals. However, I don't see much written about it. Someone here had some success discontinuing Klonopin using Trileptal. To my knowledge, Trileptal has no direct effects on GABA neurotransmission.
> ...getting off klono...it decreases certain serotonin stuff...
Do recall where you saw this? Some old studies reported that Klonopin reduced serotonin release.
> it can make people depressed....
I would say that this occurs in a sizeable proportion of people taking Klonopin. I am guessing that it is a minority, though. I wonder if this depressive reaction to Klonopin is significantly more common in people with underlying mood disorders.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1033537
URL: http://www.dr-bob.org/babble/20121217/msgs/1033773.html