Posted by SLS on December 23, 2012, at 21:21:14
In reply to Re: clonazepam/Klonopin and HPA axis issues » SLS, posted by sigismund on December 23, 2012, at 17:30:47
> >I think glutamate is the culprit
>
> I recall a link with a claim that methadone could be withdrawn really quickly and painlessly with high dose memantine.
>
> That would be glutamate related?Yes. Good thinking.
> I was sceptical but interested.That is interesting. Memantine is a sort of modulator of glutamate NMDA receptors. It blocks a portion of this receptor and reduces signaling. It might help reduce "background noise", but I am not sure. There are three other subtypes of glutamate receptor. I think drugs like Trileptal (oxcarbazepine) might work better than memantine because they squelch overactive glutamatergic circuits by blocking the sodium channels of those glutamate neurons that use these other three receptors.
I would not rule-out the possibility that memantine might be effective for methadone withdrawal. I don't know enough about it. I'll keep my eyes open for more information on this.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1033537
URL: http://www.dr-bob.org/babble/20121217/msgs/1033664.html