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Re: Nardil Users/Experts, what to do for B6 deficiency

Posted by gilmourr on November 30, 2012, at 12:26:55

In reply to Re: Nardil Users/Experts, what to do for B6 deficiency » gilmourr, posted by Phillipa on November 30, 2012, at 8:54:14

It's not really different WITH nardil, because your levels should just be normal again.

Nardil depletes B6 levels. This is because EITHER nardil or it's metabolite phenylethylidenehydrazine lower B6 levels. B6 is super important for the meds to work. They actually shouldn't work technically at B6 deficient levels since it's needed for neurotransmitter synthesis. Here's one passage on pubmed...

"Phenelzine reduces plasma vitamin B6.

Plasma levels of the active form of vitamin B6 (pyridoxal phosphate) in 19 patients taking phenelzine were found to be reduced on the average to approximately 54% of the value in a control group."

another...

Drug-pyridoxal phosphate interactions.

In this review it has been pointed out that vitamin B6 and its vitamers can be involved in many interactions with a number of drugs, as well as with the actions of various endocrines and neurotransmitters. Nutritional deficiencies, especially of vitamins and proteins, can affect the manner in which drugs undergo biotransformation, and thereby may also modify the therapeutic efficacy of certain drugs. The differences between nutritional vitamin B6 deficiency and the hereditary disorder producing pyridoxine dependency are discussed. In addition to a pyridoxine deficiency being able to adversely affect drug actions, the improper supplementation with vitamin B6 can in some instances also adversely affect drug efficacy


THIS may be why a lot of people say Nardil POOPS out. Maybe their vitamin levels were diminished GREATLY by taking it, so it works initially and when you have super low levels of B6 you can't get the benefits.


BTW right now I feel super tired, waking up at 1 pm (when nardil works I wake up at 7 am everyday), my motivation is shot, I feel brain dead really and confused, I'm irritable as fack and I'm having shivers that remind me of withdrawal 24/7.

Somethings wrong, Phillipa do you know who the Nardil experts are on the board? I seriously believe that we have a better chance at solving this than doctors as it's just way too specific.
And I don't have a psych till january 15th :(

(Also folate and B12 are required as well for NT synthesis). I really should have all levels checked but B6 is the more obvious one since Nardil/hydrazines diminish it greatly with each dose.


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poster:gilmourr thread:1032164
URL: http://www.dr-bob.org/babble/20121130/msgs/1032185.html