Posted by SLS on November 11, 2012, at 6:27:26
In reply to Re: How to battle anticholinergic amnesia?, posted by sk85 on November 10, 2012, at 13:33:53
> > > Well I'm back on clomipramine. It just works so well for a lot of things that are going on in my life, from dystonia to OCD.
Isn't it precisely the anticholinergic effects of clomipramine that are improving the dystonia?
> Pilocarpine has the potential to induce epilepsy, so I'd rather not go there.
A friend of mine has been taking pilocarpine for quite awhile to treat salivary insufficiency. So far, no seizures.
> Aricept is interesting. But has anyone not suffering Alzheimer's taken it and found it useful?
I know two people with depression who have found Aricept helpful to improve depressive and cognitive symptoms. In each case, however, the improvement failed to persist over time.
> Cholinesterase inhibitors can have on their own right numerous SEs.
Which ones in particular concern you?
> A more interesting question would be, does tolerance develop to the anticholinergic effects, or is this a false hope?
For how long have you been taking clomipramine?
For me, the anticholinergic effects of imipramine diminished over time. There were some residual cognitive effects, but I found them to be acceptable.
If you do decide to discontinue clomipramine, you may want to taper gradually in order to prevent a cholinergic rebound that could include a worsening of dystonia.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1030937
URL: http://www.dr-bob.org/babble/20121029/msgs/1031060.html