Posted by ChicagoKat on October 3, 2012, at 9:31:00
In reply to Re: Jono, sorry to bother you, but need rpt info » ChicagoKat, posted by SLS on October 2, 2012, at 22:42:43
> > > > But I've been meaning to ask you, to ask you all, actually...do you know of any interactions between smoking and Nardil or Nortryp? I mean like kinetic and metabolic interactions that could lower blood concentrations, that sort of things. I've checked my references and they've mentioned nothing, but I thought I'd pass it by you too.
> > >
> > > There should be no pharmacokinetic interaction between Nardil and nortriptyline.
> > >
> > > I reviewed the metabolism of Nardil recently, and I could find no data indicating that cytochrome enzymes are involved. Nor does it seem that Nardil inhibits any. Tricyclics are metabolized by cytochrome enzymes. The main metabolic pathway for Nardil metabolism is actually oxidation via MAO. Nardil inhibits its own metabolism. Nardil is also metabolized via acetylation, albeit to a lesser extent.
> > >
> > >
> > > - Scott
> >
> > Maybe I misunderstood, or maybe you did Scott, but I was asking about interactions between SMOKING and nardil and/or Nortryp.
> > Kat
>
>
> Oh. Sorry...
>
> I have never encountered any research nor has any doctor ever mentioned to me any kind of interactions between smoking and these two drugs. I think you would be in a better position than me to research it. I am not familiar with how smoking affects the levels of different drugs. If smoking is an inhibitor or inducer of CYP2D6, nortriptyline levels would be affected. CYP1A2 is only a minor metabolic pathway.
>
>
> - Scott
>
>I think they are OK, based on the info you gave me. But did you know smoking decreases blood levels of Xanax by 50% in smokers? I think I'm gonna make a general announcement b/c research has shown that 43% of depressed people are smokers, and of them I'm sure a fair number take Xanax.
Thanks for all the info Scott, you're so darn intelligent!
Kat
poster:ChicagoKat
thread:1027203
URL: http://www.dr-bob.org/babble/20121001/msgs/1027427.html