Posted by ChicagoKat on October 2, 2012, at 9:02:33
In reply to Re: Jono, sorry to bother you, but need rpt info » ChicagoKat, posted by SLS on October 1, 2012, at 22:08:45
> > > Sorry, that should read "I'd start on 15mg of nardil and 25mg of nortriptyline"
> > >
> > > I'd then aim to be at your full dose (nardil 45mg and nortriptyline 75mg) after 1-2 weeks, depending on side effects
> > >
> > > Some people find nortriptyline very sedating, others hardly at all - let how you're feeling be your guide to the dose increases.
> > >
> > > Scotts approach has a lot of merit - you've been ill for years, and extra week for dode titalation isnt going to make much difference in the big picture
> > >
> > > Best of luck
> > >
> > > J
> >
> > Thanks Jono...I tend to agree with you, I'd like a faster approach and I'm sure I can tolerate it..I tend to adjust to meds pretty quickly (sorry Scott!)
>
> Don't worry about it. From what you wrote earlier in this thread, I was just under the impression that you were extremely med-sensitive. If you can tolerate a more rapid titration, I see no reason why you should not be able to arrive at your target dosages sooner than what I suggested. Just be aware that you will not get the full effects of Nardil right away. Don't be lulled into a false sense of security. It might take a full week for a peak accumulation of monoamine neurotransmitters to occur after a dosage increase. This can produce a delay in the emergence of side effects. I am still concerned about a synergism in the production of hypotension and urinary retention. Otherwise Jono's suggestion is reasonable. Good luck.
>
>
> - ScottHi Scott, hope you are well.
I do have to tell you that I experienced a complete disappearance of my anxiety within a week of starting Nardil ( and remember, like I told you, it had been ramped up veery fast). I am aware it takes longer, weeks even for the anti-depresant effects to kick in, and at my relatively low dose it may take much longer if ever.
I really appreciate your concern over the autonomic SEs with the combo. With the hypotension especially. I have a BP monitor, and I will use it multiple times through the day. I will also pass on your concern to my pdoc today.
Also, I will smoke LOL..yes, sadly I'm a smoker, but I onlly smoke 2 or 3 a day. It's played hell with my BP up to this point, but with the Nardil and Nortryp., it may be a good thing...a good quick rescue if my BP goes way too low.
But I've been meaning to ask you, to ask you all, actually...do you know of any interactions between smoking and Nardil or Nortryp? I mean like kinetic and metabolic interactions that could lower blood concentrations, that sort of things. I've checked my references and they've mentioned nothing, but I thought I'd pass it by you too.
Thanks!
Kat
poster:ChicagoKat
thread:1027203
URL: http://www.dr-bob.org/babble/20121001/msgs/1027289.html