Posted by phidippus on September 15, 2012, at 15:57:04
In reply to Re: Pristiq dosages of 200 - 400 mg/day. » jono_in_adelaide, posted by SLS on September 15, 2012, at 7:05:09
One thing you can do is look into the neurotransmitters and the effects they have.
"And what's the deal with clomipramine? Why is this SNRI considered more effective than any other, especially for treating melancholic depression? Calcium channel inhibition? Sodium channel inhibition? Sigma receptor stimulation? 5-HT2a receptor blockade? Muscarinic receptor blockade? NMDA receptor modulation? Opioid kappa and delta receptor stimulation? Glutamate receptor blockade?"
say, for instance, sodium channel inhibition is shown to have negligible effects on mood. Sigma receptor stimulation results in inhibition of ion voltage gated channels-how this effects mood is unknown. NMDA receptor modulation may or may not affect mood, etc.
Of course, all of these chracteristics could add up.
The only thing we can't account for is the individual's reaction to any single medication
In my case, Viibryd proved too be a more powerful anti-obsessional than Clomipramine was. What? Why?
All I know is if a medication has 5ht1a partial agonism, I respond strongly.
Eric
poster:phidippus
thread:1024121
URL: http://www.dr-bob.org/babble/20120912/msgs/1025725.html