Posted by schleprock on August 20, 2012, at 16:48:16
In reply to Re: Nortriptyline x Clomipramine » schleprock, posted by phidippus on August 20, 2012, at 14:24:16
> Clomipramine is considered the 'gold' standard for treating depression.
>
> 1. It is not a forgone conclusion switching from one pooped-out TCA to another will make little difference. Each TCA has a different and specific mechanism of action. For instance, Clomipramine antagonizes dopamine, whereas Nortryptaline does not.
>
> 2. I wouldn't expect withdrawal symptoms especially if you cross-taper between each medication.
>
> Effexor and Nortryptaline are both SNRIs and have similar modes of action.
>
> Eric
>Thanks. Due to this and a response on another forum, I might actually be looking forward to this. Do you know offhand if Clomipramine requires the same plasma-level testing (for the "therapeutic window") that Nortriptyline does?
poster:schleprock
thread:1023735
URL: http://www.dr-bob.org/babble/20120818/msgs/1023751.html