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Re: Nortriptyline x Clomipramine » schleprock

Posted by phidippus on August 20, 2012, at 14:24:16

In reply to Nortriptyline x Clomipramine, posted by schleprock on August 20, 2012, at 11:49:50

Clomipramine is considered the 'gold' standard for treating depression.

1. It is not a forgone conclusion switching from one pooped-out TCA to another will make little difference. Each TCA has a different and specific mechanism of action. For instance, Clomipramine antagonizes dopamine, whereas Nortryptaline does not.

2. I wouldn't expect withdrawal symptoms especially if you cross-taper between each medication.

Effexor and Nortryptaline are both SNRIs and have similar modes of action.

Eric


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URL: http://www.dr-bob.org/babble/20120818/msgs/1023741.html