Posted by phidippus on August 20, 2012, at 14:24:16
In reply to Nortriptyline x Clomipramine, posted by schleprock on August 20, 2012, at 11:49:50
Clomipramine is considered the 'gold' standard for treating depression.
1. It is not a forgone conclusion switching from one pooped-out TCA to another will make little difference. Each TCA has a different and specific mechanism of action. For instance, Clomipramine antagonizes dopamine, whereas Nortryptaline does not.
2. I wouldn't expect withdrawal symptoms especially if you cross-taper between each medication.
Effexor and Nortryptaline are both SNRIs and have similar modes of action.
Eric
poster:phidippus
thread:1023735
URL: http://www.dr-bob.org/babble/20120818/msgs/1023741.html