Posted by Alexei on April 24, 2012, at 12:52:52
In reply to Re: Scott et al...dopamine agonist + Effexor? » Shes_Initforthemoney, posted by SLS on March 25, 2012, at 5:14:54
> Would you consider trying a low dose of Abilify first? As a partial DA agonist, it acts to gently increase dopamine flow when levels in the synapse are low. By contrast, pramipexole, as a full agonist, should be more likely to cause a downregulation of postsynaptic DA receptors, leaving them less sensitive than when you started. This is speculation on my part. However, what is not speculation is that pramipexole can cause sleep attacks, especially at low dosages.
> I have seen only one report on Psycho-Babble of a robust response being associated with pramixole treatment. By contrast, there are multiple reports of Abilify being effective at dosages ranging between 2 - 5 mg, usually when used as an adjunct to other drugs in unipolar depression. For bipolar depression, the dosage might have to be higher. I need a minimum of 10 mg for Abilify to have good effect.
> I like Effexor. Two drugs that I know work to augment Effexor are Wellbutrin and nortriptyline. Of course, Abilify is a valid option.
> - Scott
To Scott or anyone ...May I ask your experience of effexor ... and why you stopped it? I'm having decent results at 225mg but not good enough.
My doc actually offered me both nortriptyline and abilify for augmentation. Can you use both... or by what criteria do you choose? What dose of nortriptyline are you thinking of here?
I am taking vyvanse as prescribed. Is this med capable of causing this downregulation of DA receptors? ... I do not abuse it in the least..
Thanks
poster:Alexei
thread:1013872
URL: http://www.dr-bob.org/babble/20120411/msgs/1016322.html