Posted by SLS on March 25, 2012, at 5:14:54
In reply to Scott et al...dopamine agonist + Effexor?, posted by Shes_Initforthemoney on March 24, 2012, at 22:09:23
> I was wondering what you guys thought of adding a dose of a dopamine agonist like pramipexole to my 225 mg dose of Effexor XR? I am looking at trying to slightly stimulate the few dopamine receptors pramipexole can do.(As high dose Effexor tingles the dopamine a little bit.) Mostly, to enhance sex drive, but take away a bit of the apathy ad's can cause.
Would you consider trying a low dose of Abilify first? As a partial DA agonist, it acts to gently increase dopamine flow when levels in the synapse are low. By contrast, pramipexole, as a full agonist, should be more likely to cause a downregulation of postsynaptic DA receptors, leaving them less sensitive than when you started. This is speculation on my part. However, what is not speculation is that pramipexole can cause sleep attacks, especially at low dosages.I have seen only one report on Psycho-Babble of a robust response being associated with pramixole treatment. By contrast, there are multiple reports of Abilify being effective at dosages ranging between 2 - 5 mg, usually when used as an adjunct to other drugs in unipolar depression. For bipolar depression, the dosage might have to be higher. I need a minimum of 10 mg for Abilify to have good effect.
I like Effexor. Two drugs that I know work to augment Effexor are Wellbutrin and nortriptyline. Of course, Abilify is a valid option.
Of course, I hope you do well with pramipexole should you opt to try it first.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1013872
URL: http://www.dr-bob.org/babble/20120316/msgs/1013904.html