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Re: Does abilify work for anhedonia

Posted by n_shrimpie on February 9, 2012, at 10:44:19

In reply to Re: Does abilify work for anhedonia, posted by SLS on February 9, 2012, at 6:59:20

> > n_shrimpie,
> >
> > I take 5 mg of Abilify and have taken up to 10 mg of the medication, and I haven't noticed a reduction in the severity of my anhedonia since I've been on the drug. I don't know if Abilify might help others with anhedonia, but I just wanted to relate my experience with the medication as it relates to anhedonia.
> >
> > Tomatheus
>
> I forgot to mention that I take antidepressants along with Abilify. Without antidepressants, I don't know if Abilify would help improve my anhedonia. Probably not. Abilify can work well with Lamictal if you are trying to avoid antidepressants.
>
> Perhaps I exaggerate in my mind the positive effects that I think Abilify has on my anhedonia. However, Abilify is the only AP that acts to stimulate dopamine D2/D3 receptors as a partial agonist. D3 receptors in the nucleus accumbens are thought to mediate feelings of pleasure and reward. Currently, there is a new drug being investigated as an antidepressant that is, like Abilify, a D2/D3 partial agonist. Designated OPC-34712, this drugs is a product of Otsuka Pharmaceuticals, the developer of Abilify.
>
>
> - Scott

I read the opposite in another post; that abilify suppresses the type of dopamine that provides pleasure/reward. i might just go back to the mao's and try selegeline instead of nardil, and maybe use the abilify to counteract the daytime exhaustion, though that doesn't address the insomnia and weight gain I had on Nardil.


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URL: http://www.dr-bob.org/babble/20120202/msgs/1009808.html