Posted by CaptainAmerica1967 on November 1, 2011, at 4:48:31
In reply to Re: opiates and major depression, posted by alchemy on October 31, 2011, at 19:54:54
> > I have suffered from depression for over 30 years and have tried about every antidepressant on the market to no avail. I've even had 17 sessions of ECT which left me with nothing more than a bad memory and a huge bill.
>
> Tears are flowing with hearing about the 30 years of depression. I am about to turn 39 and I am almost at 30 years at well. I've had ECT, TMS, and meds galore. To be so close to 40 with no progression in any area, because it's a challenge to get through the day.
>
> I support opiates being used for depression at a certain point. You definitely have reached that point.
>
> I didn't feel anything from Percocet. Doesn't that have some opiate in it?You're lifelong history sounds similar to mine possibly; over 100 medications (labeled and off labeled, some non-FDA or UK approved meds) in my lifetime since this dreadful disease started when I was 16y/o and am currently 44y/o equals 28 years but feels like more as I used to use sleep deprivation two to three nights in a row a week while on Nardil by being on a super high dose (increases cortisol too) but as soon as I got any amount of REM sleep, back to the TRD ( I also have REM sleep disorder-muscles aren't paralyzed during REM sleep and like most depressed patients, fall into REM sleep too quickly-shortened REM latency, but the sleep deprivation made me feel completely normal for those days except being sleepy (my brain had to have calmed down from overactivity without recharging via REM sleep deprivation-same theory with Deep Brain Stimulation now that all depressed patients have overactive brain area's as shown on PET and SPECT SCANs and only with remission of depression does the brain calm down to being normal-instead of overactivity of blood flow/uptake of glucose; DBS by constantly stimulating certain areas of the brain like stimulants calm the ADHD patient, calm the overactive TRD patient's brain but after 15 years of sleep deprivation and several close calls of being in an accident, I gave it up.
The 70 ECT at the age of 18-19y/o in 1985-1986 didn't have any positive effect or help and I developed REM sleep disorder/behavior after all of the ECTS, but don't know if it caused it.I haven't been on psycho-babble for awhile until several weeks ago when I mentioned the positive effect buprenorphine for the refractory depressed patient, particularly the only kappa opioid antagonist in use and in my belief from readiing and in the minds of some other physicians, psychiatric researchers, believe that this is the reason behind bup (Subutex's) success with severe, chronic, daily treatment resistant depression even with anxiety. Bup calms the brain by blocking kappa receptors that seem to be overactive as stated by Richard Greer, M.D. of NAABT. Several pharmaceuticals being worked on as kappa opioid antagonist.
If you've been depressed that long like me, I'm willing to try almost anything that isn't going to kill me or severely damage me in any way. You'll take an antidepressant the rest of your life of some form so physicians or the FDA that get upset with psychiatrists that RX buprenorphine for depression is wrong. Would they rather you kill yourself or not have an active or productive live just because there's a potential for addiction with buprenorphine but a lot less than other opioids. I've tried tramadol and it didn't do much and morphine in the ER which made me feel better but not better like buprenorphine.
I'm surprised you tried TMS after having had ECT (unless you tried TMS first)as most psychiatrist or the ones I've spoken to like Ivan Goldberg, M.D. (Depression Central website) who only treats the toughest of all patients, says he tells his patient not to waste their money on TMS if they've already had ECT and ECT didn't help. Remember, some psychiatrist are business professionals too wanting to make tons of money and if they have spent money on a TMS machine/device (very expensive) and you walk into their office and tell them you've already tried ECT, they might say I think you stil should try the TMS device when I think it would be a waste of money.
My goal is finish my medical autobiography with tips that psychiatrist never mention including physical exercise, cold water-shower-bath therapy, sleep deprivation and some others and my whole experience and thoughts about the disease in a way to prevent suicide in the future as suicide (not all suicides from depression, but many are) according to the World Health Organization thinks it likely that suicide will be the number 2 killer second only to heart disease by the year 2020. Many suicides aren't reported and that's why it's not ranked higher currently, but that will change in the near future.
Best wishes in trying buprenorphine-Subutex if you plan to try it. 1995 Harvard Study by Bodkin and currently a clinicaltrials.org is studying the effects of bup in late life TRD (BUILD study?).
I'm waiting for a DBS study even though I've tried to get into two but was excluded because I had several seizure on 1000 mgs of trazodone or medication induced seizure, but will without that part out and that I had 70 ECT as the same psychiatrist did both and will always get excluded from a study as they want no other history of any neurological problems whether drug induced or having an actual disease.
poster:CaptainAmerica1967
thread:81414
URL: http://www.dr-bob.org/babble/20111027/msgs/1001412.html