Posted by floatingbridge on October 10, 2011, at 15:33:15
In reply to Re: Topiramate, potential fear extinction in PTSD, BPD » floatingbridge, posted by SLS on October 10, 2011, at 14:48:24
Looks like real world dosing is 175mg average within a range of 25mg to 500mg. Don't know how the average is calculated.
So 100mg 'may not' reduce cognitive functioning too greatly? (Yes, ymmv.). I will remember your note about the gradual titration if it ever come to it.
Because, I gotta say, something that might work with consolidated memory sounds good to me. Would be a boon
to reconditioning maladaptive thought and behavior.> Very interesting.
>
> It should be noted that the dosage (10mg/kg body weight) of topiramate used for the experimental rats was 3 - 4 times higher that used in treating humans. I can't imagine anyone taking 800mg of topiramate and not suffering impairments in cognition and memory. What if a lower dosage (100mg) was arrived at using a very gradual titration schedule? Most people can avoid or minimize cognitive side effects when topiramate is administered this way. Would topiramate still act to squelch and reverse PTSD in rats at the lower concentrations currently used clinically to treat epilepsy in humans? I would hope that the efficacy of topiramate in preventing or reversing PTSD in humans is not dependent upon transforming someone into a blithering idiot.
>
>
> - Scott
I dig a pony.
poster:floatingbridge
thread:999345
URL: http://www.dr-bob.org/babble/20111006/msgs/999354.html