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Re: Topiramate, potential fear extinction in PTSD, BPD » floatingbridge

Posted by SLS on October 10, 2011, at 14:48:24

In reply to Topiramate, potential fear extinction in PTSD, BPD, posted by floatingbridge on October 10, 2011, at 13:39:50

> Full text article:
>
> http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120893/?tool=pmcentrez


Very interesting.

It should be noted that the dosage (10mg/kg body weight) of topiramate used for the experimental rats was 3 - 4 times higher that used in treating humans. I can't imagine anyone taking 800mg of topiramate and not suffering impairments in cognition and memory. What if a lower dosage (100mg) was arrived at using a very gradual titration schedule? Most people can avoid or minimize cognitive side effects when topiramate is administered this way. Would topiramate still act to squelch and reverse PTSD in rats at the lower concentrations currently used clinically to treat epilepsy in humans? I would hope that the efficacy of topiramate in preventing or reversing PTSD in humans is not dependent upon transforming someone into a blithering idiot.


- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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