Posted by desolationrower on June 24, 2011, at 20:39:51
In reply to Re: BDNF in depression and fibromyalgia » hyperfocus, posted by SLS on June 24, 2011, at 5:13:12
> > The interesting thing is I've found that the effect of amitrip on my day-to-day functioning is best when in the range 150-225mg. Anything higher makes me feel much, much worse.
>
> That is interesting. It's almost like the therapeutic window that exists for nortriptyline. I never understood why nortriptyline should demonstrate this effect and not amitriptyline.
>i think i posted a study here once that the norep reuptake pump is not as saturated as the 5ht pump. Also, don't discount statstical flukes+hysterysis/suggestion/placebo.
> > Fish oil, flaxseed oil or anything with significant Omega-3 also seems to exert this pronounced negative day-to-day negative effect on me.
>
> Fish oil has twice exacerbated my depression within 6 hours of taking my first dose. Strange. A biochemist friend of mine and I both have come to suspect that there is something pharmacological going on here. That some people become manic on fish oil would seem to indicate such. Of course, I really don't know. It's just a hunch. Real scientific, eh?
>NSAIDs work on pain w/in hours, so atleast the affect on COX-enzyme metabolites could occur that quickly (i'm assuming fats absorbed from GI track, lymph system, blood are primary source of trigs used to create those molecules)
> > I've always suspected that while these drugs and supplements exert their effects on neurogenesis and neuroplasticity, they can actually make our day-to-day symptoms considerably worse. Do you thing this is possible - drugs that do actually repair brain structures but also make us feel much worse? Maybe we should look towards always taking these neurotrophic drugs and trying to combat their adverse effects on our symptoms some other way?
making yoru brain plastic makes it succeptable to change both good and bad. it lets you fix things, but you can re-fubar them, too.
> Pretty creative. I wish Zyprexa didn't carry with it such a metabolic liability. It would seem to me to be a good choice to fit your protocol.
>
> Personally, I have never taken a drug that initially exacerbated my depression that later went on to produce an improvement. I was so disappointed when both fish oil and phosphatidylserine made me feel worse. I had thought that combining these two substances with lithium would enhance neuroplasticity and make me feel better.
>
> So much for my personal theories. Maybe it would work for someone else.
>
>
> - Scott-d/r
Better living through chemistry, socialism, and big phallic rockets (with a side of roquette)
poster:desolationrower
thread:989086
URL: http://www.dr-bob.org/babble/20110619/msgs/989347.html