Posted by hyperfocus on June 23, 2011, at 16:51:26
In reply to Ketamine mechanism: Rapid AD response., posted by SLS on June 22, 2011, at 13:37:45
Amitriptyline is an AD that has pronounced long-term positive effects on BDNF production. Curiously, nortriptyline does not. This is unfortunate because the side-effects of amitriptyline are very harsh and not many people can tolerate therapeutic doses of it, so not many doctors are willing to prescribe it ahead of SSRIs and newer drugs. BDNF may also be a factor in fibromyalgia so it could explain why amitriptyline is effective in treating these conditions.
http://www.ncbi.nlm.nih.gov/pubmed?term=amitriptyline%20BDNF&itool=QuerySuggestion
I'm partial to the theory that treating depression and MI has more to do with repairing and regrowing areas of the brain that are damaged and have atrophied, than raising or lowering neurotransmitter levels.
http://www.neurotransmitter.net/depressionfactors.htmlC-PTSD: social phobia, major depression, dissociation
Currently on 150mg amitriptyline single dose at night.
Improving.
poster:hyperfocus
thread:989086
URL: http://www.dr-bob.org/babble/20110619/msgs/989214.html