Posted by g_g_g_unit on May 8, 2011, at 4:42:24
In reply to Re: ughhh (Zoloft + Depakote), posted by creepy on May 8, 2011, at 0:49:17
> Do you think youre being pushed into a mild mixed state? Irritability? Feeling hurried? Thats what Id expect depakote for.
> zoloft supposedly does a little dopamine RI at higher doses but Im not sure where and how much that takes place. A lot of folks say theyve had akathisia on it. It has probably the worst reputation of all the SSRIs for causing mixed state stuff, but its the one SSRI that hasnt done that to me so far. Go figure!
> a doc could misinterpret akathisia as anxiety or agitation. Do you have a therapist as well, that you could bounce that off of? Someone that has a history of observing you?I'm starting to wonder if it may be some kind of mixed state, though I'm not certain. I've had full-blown akathisia on Prozac, but I explained to my doctor that the restlessness on Zoloft is a little milder (though I was taking 20mg Prozac vs. 25mg Zoloft). I'm still also unclear as to whether what I experienced on clomipramine was akathisia or something else, but like I say, I do seem prone to overstimulation - reacting strongly to even tiny stimulant doses.
I do find myself feeling hurried, yeah. Like when I'm walking, I find I walk a lot faster and more urgently for some reason. I'll also feel like I constantly need to be doing something throughout the day and almost overschedule, though I'm not sure if that's an OCD thing because my OCD/obsessiveness has been a lot worse as well. And yeah, I am more irritable and quite depressed overall, despite being more productive during the day.
I don't believe Zoloft only affects dopamine at higher doses. Even if the DRI is weaker at this dose, sigma antagonism will increase dopamine, which might explain the increase in OCD.
I'm in CBT, but we mostly deal with OCD.
I'm still not sure if the Depakote is supposed to be an antidote to the agitation/mood symptoms or 'akathisia' and insomnia. Either way, it's still disrupting my sleep. I suppose my original post was also meant as an inquiry into whether the sx. are transient. I tried taking it with Xanax last night and slept better - and felt more stable today - but mood stabilizers do quite a number on my cognition. The plus is that I could freely ingest nicotine/caffeine today without panicky/overstimulated.
poster:g_g_g_unit
thread:984764
URL: http://www.dr-bob.org/babble/20110502/msgs/984888.html