Posted by SLS on April 14, 2011, at 4:59:40
In reply to Re: Nortriptyline vs reboxetine » SLS, posted by Bob on April 13, 2011, at 23:43:34
> I thought I saw a post recently where you said that after an extended time on lithium it began to have an antidepressant effect that you had not expected?
Yes. In fact, I began to improve within two days.
I must have hit a bump in the road this past week that was simply a worsening associated with the natural course of my illness rather than a lithium-induced worsening. I rechallenged myself with lithium 300mg and have recaptured the antidepressant effect. I like this drug (today). Interestingly, Harvard / Mass General determined that low dosages of lithium (300-600mg) act as an augmenter of antidepressants in MDD. Most patients whom responded did so at a dosage of 450mg. The antidepressant used in the study was fluoxetine. There is substantial indication in the medical literature that lithium added to a tricyclic can produce a rapid and robust improvement. It is nice to know that lithium can also augment a SSRI. Unfortunately, there are no studies I know of that compares the rate of response to an SRI versus a tricyclic when lithium is added.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:981366
URL: http://www.dr-bob.org/babble/20110406/msgs/982765.html