Posted by Conundrum on April 5, 2011, at 14:42:25
In reply to Re: From which dose venlafaxine is stimulant?, posted by bleauberry on April 4, 2011, at 5:03:33
> I wouldn't count on effexor for stimulation. I mean, sure, it could give some of that stimulation that some people feel from boosted serotonin, which is usually a short term phenomenon.
>
> The best med is the one that feels best to you. No study is going to tell us which one that is. In the studies determining which is superior, they are naturally biased depending on who sponsored and wrote the study. All meds at one time or another have been deemed superior to others. But even the ones that were superior...were only superior by a few percentage points...nothing to celebrate about.
>
> All that said, I've heard effexor begins to get more stimulating about 225mg, and more so around 350mg. Those doses are where its very small effect on norepineprhine and dopamine begin to have some slight relevance compared to serotonin.I agree everyone will respond differently. When I started desvenlafaxine I found it immediately stimulating and could not sleep the first night. I never experienced this with lexapro or prozac, so I'm guessing it had to do with its effect on norepinephrine, which is *claimed* to be 10:1 in favor of serotonin as opposed to the venlafaxine molecule which is 30:1 in favor of serotonin, which when couple with the metabolite in the blood must be somewhere in between those ratios. I was able to sleep fine on this drug over time though. I never found it sedating though. Some people find adrenergic drugs tiring so YMMV.
Complaints: post-SSRI problems: anhedonia, memory and concentration problems, sexual anhedonia. )
Country:USA
Currently taking 2.5 mg prozac, Multi B vitamin
poster:Conundrum
thread:981641
URL: http://www.dr-bob.org/babble/20110321/msgs/982023.html