Posted by mtdewcmu on April 1, 2011, at 20:50:47
In reply to Re: From which dose venlafaxine is stimulant?, posted by linkadge on April 1, 2011, at 20:27:46
> Thats what I don't understand. Remeron is not really dual acting (at least in the way effexor is). I also continually see people quit remeron for lack of sustained efficacy.
>Remeron is multiply-acting. It blocks alpha2 adrenergic, 5-ht2a, 5-ht2c, and 5-ht3 receptors. I don't know if that makes it as effective as they say, but why would Remeron's makers be better at influencing the scientific publications than anyone else?
> The statistical methods for comparing antidepressant efficacy is highly controversial.
> Drug A might beat B and B might beat C, yet C also beats A. It depends on what weighting factors you give to efficacy and tollerability in your overall rating. It also depends on what studies you include and how you rate the study's overall believability. I.e. if you remove studies funded by the drug company, would you get the same results? Yes, escitalopram is rated highly, but most of the positive studies are industry funded.I think when they do those meta-analyses, they reinterpret the raw data, rather than relying on the interpretations of the original authors. Not completely sure though.
poster:mtdewcmu
thread:981641
URL: http://www.dr-bob.org/babble/20110321/msgs/981682.html