Posted by mtdewcmu on April 1, 2011, at 14:51:08
In reply to Re: Remeron good then horrible anyone?, posted by Cydnie on April 1, 2011, at 12:23:46
> I'm so glad to hear from other people who had similar experiences. I seemed to go from being really happy, to feeling a little more down, to more, to more, and then despair. I strangely fell asleep last night very early without even taking it, and still feel really depressed (as well as really anxious because I finally found something that worked). The weird thing is I started out the mornings okay, and as I went along, got worse, not because anything happened, but I don't know, chemistry I guess. Circadian rhythm? I have no clue. I had been taking melatonin with the remeron (it never made me tired except for in the very beginning) and went up to 9 mg and it worked great. I thought maybe it was that, so I stopped that a few nights ago, but I still don't feel better. I hate this, it's so scary being this depressed, this despair, and I'm scared of getting worse. I decided to take a sam-e and see if I felt better. Yesterday I tried 1/2 an amitryptilene, but I think it just made me really tired, weird. I also take adderall which has always helped my mood, shut the bad self-criticism down, and I was able to motivate myself to do so much, and felt like a good Mom. Now I am back to being a mess, and terrified of getting worse. I hate this!
If I were you, I would stop taking Adderall. Powerful stimulants can make you feel good, or they can make you feel really bad. Adderall is not an antidepressant, so it's unlikely to help your immediate situation, and it could seriously aggravate anxiety. If you get withdrawal, you could take a lower dose. Moreover, it could be having a negative interaction with Remeron.
Melatonin has been rumored to be capable of causing depression with long-term use. I would set that aside, too.
Taking one pill of SAMe here and a little amitriptyline there is not likely to do any good. The name of the game is to simplify and give each chemical a chance to work.
The reason that you feel different at different times of the day could be due to the fact that the levels of drugs in your system varies throughout the day. Remeron has a half-life of about a day, so if you take it once at night, you will have roughly half as much in your system by the next night.
As an aside, I read about a kind of time-release trazodone being approved by the FDA (Oleptro), but I don't see it for sale anywhere. Trazodone is kind of similar to Remeron, and having it delivered at an even rate is supposed to make the side effects tolerable.
poster:mtdewcmu
thread:981556
URL: http://www.dr-bob.org/babble/20110321/msgs/981655.html