Posted by Christia on March 31, 2011, at 22:25:01
In reply to Re: Alpha-delta sleep and cymbalta? » Christia, posted by desolationrower on March 30, 2011, at 21:15:58
Hi,
I've tried imipramine, desipramine, and one other (not sure which--long time ago).
I seem to be incredibly sensitive to meds. I tried every one of the SSRIs in turn. None worked for me. Most made me sleepy, some more than others. Effexor made me super-tired but at least worked on the depression. Had to sleep 10 hours/night on 37.5 and 12 on 75 mgs. I was a grad student at the time so I could actually live with that.
Cymbalta has been by far the best, has always made me somewhat fatigued but that seems worse now. I'm not sure why that would be?
This site is great! So much knowledge. I have to look up 5ht2c and 5ht2a to see what they are. Had to look up cyproheptadine as well. WOuld this be to improve sleep?
Thanks again!
> yes, i think that would be close to as good. 5ht2c inhibition is about 2x as effective as 5ht2a inhibition. I would worry that it won't help the fatigue, if it is the sri effect of duloxetine that is causing it. have you ever taken an ssri, and did you have fatigue?
>
> which TCA did you try before? desipramine and notriptyline have less side effects than some of the others.
>
> You could also ask about cyproheptadine. it is an antihistamine as well as 5ht2 antagonist, but it has a reasonably short half-life.
>
> -d/r
poster:Christia
thread:981150
URL: http://www.dr-bob.org/babble/20110321/msgs/981604.html