Posted by Chairman_MAO on February 3, 2011, at 14:31:15
In reply to Re: Questions On Depression and Nardil » luckyduck, posted by pedr on February 3, 2011, at 13:36:45
>For instance, there is no research whatsoever on the body weight 1kg / 1mg ratio. It's a rule-of-thumb that some psychs employ but certainly not all. My (competent) psych had never heard of it.
You are wrong, and so is your doctor--unless you misrepresented what he said, which is possible.
"Clinical response to phenelzine is related to platelet MAO inhibition and dosage per unit body weight."
http://www.ncbi.nlm.nih.gov/pubmed/365127
And that's from 1978! Nothing earth-shattering here.
Yes, it is a heuristic, and clinical response matters most. However, it is based on research: unless you get blood work done and follow platelet MAO, one should titrate to desired effect, which seems to happen around 1mg/kg/day. People with abnormal liver function, etc., need not apply.
I have no medical degree, but I can read and understand concepts.
"No research whatsoever" is a strong statement!
poster:Chairman_MAO
thread:976577
URL: http://www.dr-bob.org/babble/20110130/msgs/978611.html