Posted by Conundrum on December 15, 2010, at 12:40:02
In reply to Re: Valdoxan (agomelatine) » medamorphosis, posted by SLS on December 15, 2010, at 4:32:25
Sorry to butt in, sounds like what happened when i tried remeron, it started to work a week and a half later than stopped. 5 HT2C antagonism is great, but I think sometimes you need an increase in serotonin to keep it from pooping out. Perhaps 5 HT1a agonism keeps the dopamine norepinephrine disinhibition going?
> Hi.
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> > Well 2hrs ago I took my 1st 25mg. Feel it already!
>
> Yes. I believe that this is possible. I took my first dose of Valdoxan at bedtime. I woke up feeling significantly better. No placebo here. However, this antidepressant response lasted for no longer than three days. I was surprised that it returned two weeks later. Unfortunately, after another three days, I relapsed and quit taking Valdoxan, perhaps prematurely. I have since added Abilify and am receiving significant from it. I am very seriously thinking about re-trialing Valdoxan, now that Abilify is onboard and the terrain of my brain has changed.
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> - Scott
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>
Complaints: post-SSRI problems: anhedonia, memory and concentration problems, sexual dysfunction. )
Country:USA
Currently taking SAM-e 1200mgs
poster:Conundrum
thread:973537
URL: http://www.dr-bob.org/babble/20101203/msgs/973635.html