Posted by linkadge on December 12, 2010, at 20:17:46
In reply to Re: Seroquel for unipolar depression, posted by mogger on December 10, 2010, at 23:37:57
The TCA's effects on serotonin aren't as clear cut as the SSRIs. They can serotonin reuptake to various degrees, but they also inhibit serotonin receptors which can negate some of the antidopaminergic effect. Drugs like amitriptyline exhibit more of an antiserotonergic effect.
A drug like nortriptyline, has little effect on sertonin reuptake. Keep in mind, that a metabolite of seroquel is a NRI. I found that notriptyline was definately more tollerable than seroquel, and a seemingly more potent antidepressant, generally little akathesia too.
Seroquel made me feel fairly flat the next morning (i.e. colors duller etc). It was a decent sleep aid (if insomnia is promenent).
Linkadge
poster:linkadge
thread:972589
URL: http://www.dr-bob.org/babble/20101203/msgs/973324.html