Posted by Conundrum on November 6, 2010, at 12:26:39
In reply to Re: Valdoxan for sleep? vs Remeron » orbital, posted by SLS on November 6, 2010, at 6:34:22
> > melatonin makes me feel more depressed the next day).
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> Me, too. That is why I was somewhat reluctant to try agomelatine. In the end, agomelatine made me feel very much the same as did melatonin. Agomelatine is unquestionably a drug worth looking at for treating major depressive disorder. Studies show that the stimulation of melatonin receptors and the blocking of 5-HT2c receptors are necessary for the therapeutic effect. Ramelteon (Rozerem), stimulates the same melatonin receptors as agomelatine, but is devoid of serotonergic activity. Ramelteon is also devoid of antidepressant effects. If depression is not an issue, perhaps you can try ramelteon first if you find it difficult to locate agomelatine. The 5-HT2c antagonism of agomelatine might actually disturb sleep at first. This was the experience that Ron Hill and I had with this drug. 5-HT2c antagonism will increase the release of DA and NE neurons in the prefrontal cortex (PFC) and modulate dopamine release in the nucleus accumbens. 5-HT2c and 5-HT2a receptors are antagonistic.
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> - Scott
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Its interesting because remeron is an alpha 2 adrenergic antagonist and 5 HT2A/C antagonist. Alpha 2 adrenergic antagonists like yohimbine are not antidepressants but it seems that adding the 5HT2C antagonism really helps. Remeron is also a 5HT3 antagonist which by itself like in the drug ondansteron is not an antidepressant.
Complaints: post-SSRI problems: anhedonia, memory and concentration problems, sexual dysfunction. )
Country:USA
Currently taking mirtazapine and tianeptine
poster:Conundrum
thread:968721
URL: http://www.dr-bob.org/babble/20101030/msgs/968793.html