> melatonin makes me feel more depressed the next day).
Me, too. That is why I was somewhat reluctant to try agomelatine. In the end, agomelatine made me feel very much the same as did melatonin. Agomelatine is unquestionably a drug worth looking at for treating major depressive disorder. Studies show that the stimulation of melatonin receptors and the blocking of 5-HT2c receptors are necessary for the therapeutic effect. Ramelteon (Rozerem), stimulates the same melatonin receptors as agomelatine, but is devoid of serotonergic activity. Ramelteon is also devoid of antidepressant effects. If depression is not an issue, perhaps you can try ramelteon first if you find it difficult to locate agomelatine. The 5-HT2c antagonism of agomelatine might actually disturb sleep at first. This was the experience that Ron Hill and I had with this drug. 5-HT2c antagonism will increase the release of DA and NE neurons in the prefrontal cortex (PFC) and modulate dopamine release in the nucleus accumbens. 5-HT2c and 5-HT2a receptors are antagonistic.
- Scott
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this signature | Show by default | Change to hide (next time)Some see things as they are and ask why.
I dream of things that never were and ask why not.