Posted by michelle41a on October 10, 2010, at 10:41:01
In reply to Re: Zoloft too stimulating, Should I try Celexa?, posted by zatar on October 9, 2010, at 14:54:05
> Personally, I can't tolerate SSRIs at any dose - Prozac, Celexa, Lexapro, Zoloft, plus anything that has an SSRI component to it - Effexor, Cymbalta, Wellbutrin, etc. Haven't tried Savella, but don't want to. Prozac was the worst since it has such a long half life that it took a month to get out of my system.
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> There are just some people who are SSRI intolerant, not to be confused with SSRI-resistant. To assume that depression or anxiety is garden variety in everyone and that they should respond to the same meds is just nonsense. If I hear one more time that I just need to try this SSRI, or increase the dose slowly, or give it more time, I will scream. I've done all those things over 10 years and it doesn't work.
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> I found Neurontin and Lyrica to have some anti-anxiety effect, but they poop out on me rather quickly and increasing the dose gives me spaciness and other side effects I can't live with.
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> Right now I just take Valium prn, when my anxiety gets bad or I have a panic attack. Klonopin worked at 2mg, too, but above that dose it was depressogenic. :-(
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> When anxiety acts up, scrupulously avoiding caffeine, chocolate, alcohol and getting enough sleep is a must for me. When things quiet down, I can misbehave a bit and it's OK. It's also interesting that when I take too much FolaPro(L-5-methyl tetrahydrofolate, the active form of folic acid because I'm 5-MTHF homozygous), it stimulates me too much. I try to limit it to no more than 400 mcg per day. And the taurate form of magnesium also stimulates me too much, while other forms of magnesium do not.
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> Genetic variation in receptors rather than drug metabolizing enzymes seem to be involved. Remeron (mirtazpine)can be tried for SSRI intolerance because it doesn't affect the HTR2A 102 T/C genotype.
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> http://www.ncbi.nlm.nih.gov/pubmed/14514498
> http://www.ncbi.nlm.nih.gov/pubmed/11465517
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> -ZATAR
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>Hi Zatar :)
Thanks so much for the info! I just increased my zoloft dose from 12.5 to 18.75 on Oct 3rd.. I also am taking .5 klonopin 1x/day which seems to help with the anxiety.. I do feel like I am getting better, I am defintely feeling much better that I felt back in July when my anxiety was horrible :( Before I started the zoloft, I was having full blown panic attacks every day..
I have only been on the Zoloft for about a month, so I guess I will give it some more time.. I will defintely keep the Remeron in mind if the Zoloft doesn't work..
Michelle
poster:michelle41a
thread:963711
URL: http://www.dr-bob.org/babble/20101009/msgs/965237.html