Posted by Zzzz on August 27, 2010, at 2:19:41
In reply to Re: Pseudoephedrine (sudafed), posted by bleauberry on April 12, 2010, at 17:50:12
Steady state dose, daily use is not the same effect.No tolerance develops with PSE. Time release is better and urine ph can deplete or cause overdose in diets that cause strong acid or alkaline urine.
Other drugs may compete such as antihistamine may knock out the weight/calorie control. The weight loss could be studied in ataxin-3 narcolepsy syndrome mice with hypophagia and obesity. PSE is a NET substrate. It could be tested to see if it is direct and or indirect for norepinephrine by using dopamine beta hydroxylase knock out mice that can not produce norepinephrine. Ephedrine has been proven to be a direct acting drug in this manner.
Sometimes the effect of a drug is due to the balance or ratio of that chemical to the others. More is not always better. PSE may also have MAOI depending upon dose and other factors.
Low dose Beta Blockers will work with PSE. Always double check all the meds taken together at one time for interactions. PSE does not use liver CYP isoenzymes which is a relief.
Hope this helps answer a few questions. PSE also has an L-PSE which does not effect blood pressure. I have tried to suggest the market of the L-PSE but the company was not interested. It would also be good because it makes L-methamphetamine which has poor stimulant strength compared to the D-PSE which is the over counter we use now.
poster:Zzzz
thread:942830
URL: http://www.dr-bob.org/babble/20100821/msgs/960112.html