Posted by ed_uk2010 on August 1, 2010, at 12:10:26
In reply to Re: What steps should I take?, posted by europerep on August 1, 2010, at 10:09:08
>I do not entirely agree with Ed when he said there is little evidence to try venlafaxine at doses above 150mg (that is less than half of what the manufacturer indicates as the maximum dose).
I do not entirely agree with myself either!I do think that venlafaxine can be more effective at high doses than at standard doses in some cases, but it's not consistently the case. I don't think I expressed myself well in my earlier post. What I meant to say is that if there has been no response at all to 150mg/day after two months, the probability of obtaining a good response on a higher dose is likely to be low. IIRC, this is not the case for you, however :)
AFAIK, Wyeth didn't do enough studies to establish a clear dose-response relationship in the pre-approval studies for venlafaxine. Their recommended maximum dose has more to do with evidence of safety at high doses than it has to do with evidence of enhanced efficacy.
poster:ed_uk2010
thread:956554
URL: http://www.dr-bob.org/babble/20100731/msgs/956720.html