Posted by europerep on July 29, 2010, at 14:42:15
In reply to Re: Anyone had success with prozac+clomipramine???, posted by Phillipa on July 28, 2010, at 19:10:14
well, combining serotonergic agents is in itself a danger, if there are further complications through metabolism through the same cytochromes it just adds up to that, since plasma levels of the drugs might be higher than usually..
of course one must be careful, but the combination of TCAs and SSRIs in general in TRD is a possible, though unconventional strategy.. I just read an article the other day that valided that, I just happen to have read a lot of articles this week so I don't remember where exactly it was..I believe there is no serious risk in trying to reproduce the effect that the two drugs had together, by starting at a steady-state of the two drugs, only increasing one drug at time by a small amount, and then see what happens.. it's what I would do at least..
poster:europerep
thread:956248
URL: http://www.dr-bob.org/babble/20100720/msgs/956331.html