Posted by Roslynn on July 29, 2010, at 16:36:00
In reply to Re: Anyone had success with prozac+clomipramine???, posted by europerep on July 29, 2010, at 14:42:15
Europrep,
Thank you for the information.
Is the danger that you could possibly develop serotonin syndrome?
> well, combining serotonergic agents is in itself a danger, if there are further complications through metabolism through the same cytochromes it just adds up to that, since plasma levels of the drugs might be higher than usually..
> of course one must be careful, but the combination of TCAs and SSRIs in general in TRD is a possible, though unconventional strategy.. I just read an article the other day that valided that, I just happen to have read a lot of articles this week so I don't remember where exactly it was..
>
> I believe there is no serious risk in trying to reproduce the effect that the two drugs had together, by starting at a steady-state of the two drugs, only increasing one drug at time by a small amount, and then see what happens.. it's what I would do at least..
poster:Roslynn
thread:956248
URL: http://www.dr-bob.org/babble/20100720/msgs/956346.html