Posted by morgan miller on July 24, 2010, at 22:03:36
In reply to Re: toxic crap » morgan miller, posted by linkadge on July 24, 2010, at 21:53:53
> >This complicates the interpretation of the >results of the study. It is possible that >nortriptyline has no BBB effects in the absence >of barbiturate.
>
> No, because in a separate reference to this study, they compared nortriptyline and cloropromazine with the barbituate to various doses of diphenhyramine with barbituate. The diphenhydramine (a bicyclic) had no effect at any dose tested, with the barbituate.
>
> See p 33
>
> http://books.google.ca/books?id=9ykQOkpFFuEC&pg=PA33&lpg=PA33&dq=micellar+drugs+%2B+chlorpromazine+%2B+nortriptyline&source=bl&ots=53da_ifB39&sig=sU02PQmATTVB5BOohvSXgnwf60o&hl=en&ei=_qZLTMeJGoL_8Ab1tYk1&sa=X&oi=book_result&ct=result&resnum=1&ved=0CBQQ6AEwAA#v=onepage&q=micellar%20drugs%20%2B%20chlorpromazine%20%2B%20nortriptyline&f=false
>
> Linkadge
>Sure, but you can't just assume that long term use will eventually lead to increased BBB permeability. Like Scott said, there is no proof for this. Plus, is there any medication does not carry some risk for some type of negative effect in the long run. The way I see it, feel good and take care of yourself, and you may be able to somewhat offset any long term ill effects of meds. Then there is that possibility that a little toxicity may in some way be good for via hormesis. Just trying to look on the bright side.
poster:morgan miller
thread:955512
URL: http://www.dr-bob.org/babble/20100720/msgs/955785.html