Posted by bulldog2 on May 21, 2010, at 15:20:28
In reply to Re: Immipramine Causes Natural Endorphins to Drop, posted by linkadge on May 20, 2010, at 18:05:53
> Not sure I follow, the study said that chronic treatment with the drug inhibited neutral endopeptidase. Nowhere does the study say this causes endorphins to drop.
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> It could be the other way around, perhaps increased opiate production is a consequence of remission, and that endopeptidase simply increases to metabolize the extra opiate production.
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> In this study, neutral endopeptidase actually lowers the levels of substance P. Substance P inhibitors have antidepressant potential. So perhaps the upregulation of neutral endopeptidase actually lowers upregulated levels of substance P in limbic regions.
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> http://gut.bmj.com/content/52/10/1457.abstract
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> Its complex and this guy is reading too much into things.
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> Linkadge
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>LinkadgeThe guy makes the conclusions in the following paragraph. He does state the natural feel good transmitters would drop with immipramine. That was his conclusion from the study.
What is flawed in his logic? Here is paragraph.You state the opposite might actually be the case.
First, I would get off the imipramine as soon as possible. I was perplexed by your question and just did some considerable research on the effects of the drug. According to the following scientific study, for which I will post the link below, impramine significantly increases neutral endopeptidase activity in various parts of the brain, which is explained specifically in the article. The point here is that increased neutral endopeptidase activity increases the breakdown of the brain's natural painkillers, specifically enkephalins! No wonder you feel crappy! This is the opposite effect a recovering opiate addict would want, as our own endogenous, pain-killing enkephalins and endorphins have been already shut down by our opiate abuse. Further in another study I found, imipramine treatment in rats decreased tyrosine hydroxylase activity by 40% in the locus coreleus part of the brain. Tyrosine hydroxylase is the rate-limiting enzyme in the conversion of Tyrosine to the stimulatory neurotransmitters dopamine and norepinephrine,so basically the imipramine is significantly decreasing the levels of these "feel good" transmitters in your brain!
poster:bulldog2
thread:948058
URL: http://www.dr-bob.org/babble/20100514/msgs/948187.html