Posted by linkadge on May 20, 2010, at 18:05:53
In reply to Immipramine Causes Natural Endorphins to Drop, posted by bulldog2 on May 20, 2010, at 15:57:08
Not sure I follow, the study said that chronic treatment with the drug inhibited neutral endopeptidase. Nowhere does the study say this causes endorphins to drop.
It could be the other way around, perhaps increased opiate production is a consequence of remission, and that endopeptidase simply increases to metabolize the extra opiate production.
In this study, neutral endopeptidase actually lowers the levels of substance P. Substance P inhibitors have antidepressant potential. So perhaps the upregulation of neutral endopeptidase actually lowers upregulated levels of substance P in limbic regions.
http://gut.bmj.com/content/52/10/1457.abstract
Its complex and this guy is reading too much into things.
Linkadge
poster:linkadge
thread:948058
URL: http://www.dr-bob.org/babble/20100514/msgs/948066.html