Posted by linkadge on May 12, 2010, at 19:57:14
In reply to Re: Do stims increase the effects of ADs?, posted by chujoe on May 12, 2010, at 5:41:14
I never felt "great" on stims. For methyphenidate, part of the theraputic effect is thought to be conferred by d-methylphenidate, which is more selective for norepinephrine reuptake and has notable affinity for 5-ht1a (like buspar). 5-ht1a agonists are not addictive (infact they can reduce withdrawl symtpoms from drugs like heroin), and have anti-hyperkinetic effects in their own right.
I personally think that the brain quicky adapts to the pleasurable effects of dopamine reuptake inihibiton, yet other theraputic targets are still maintained.
Ritalin feels more like a mood stabilizer for me than anything else.
Linkadge
poster:linkadge
thread:947108
URL: http://www.dr-bob.org/babble/20100504/msgs/947273.html