Re: Interesting article? What do you think? » SLS

Posted by 49er on May 10, 2010, at 9:32:32

In reply to Re: Interesting article? What do you think?, posted by SLS on May 10, 2010, at 8:04:23

> Do you know whether or not he suffered from depression? Had he been personally disappointed when taking antidepressant drugs?
Not that I am aware of. If you go to his website, you can email him and ask directly.
>
> Claiming knowledge of statistics doesn't guarantee their validity. I have seen statistics indicating that the response rate of antidepressants is significantly greater than 15%. This is especially true when one includes those people who are allowed to try more than one drug, either sequentially or in combination. Under these conditions, I have seen the response rate reported as being between 75-85%, and remission rates of 60%.
Hmm, I have seen nothing like that. The Star D study was reporting 67% but that is the best I have seen.
Do you have a link to that study?
I know that is an unfair question as I will see studies and then forget where I saw them at. But I thought I would ask anyway just in case you remembered.
<<Interestingly, the rate of response to placebo has increased rapidly over the years. This has reduced the apparent margin of statistical superiority of drugs. My guess is that this is an artifact of the use of less rigorous screening for major depressive disorder (MDD) and the inclusion of more people who don't suffer from it. (Clinical investigators are payed based on the number of subjects enrolled). One way or another, this trend must be accounted for if statistics are to be of any value. It is significant that when working with inpatients or people with more severe depressions, the placebo response rate plunges. Another guess of mine is that this occurs because a greater percentage of subjects actually have the illness being investigated.>>
I will have to look up the statistics for inpatient folks and placebo rates. I haven't seen any studies on that. If you have link, that would be appreciated.
Thanks
49er

Thread

Interesting article? What do you think? Laney 5/9/10
...
Re: Interesting article? What do you think? linkadge 5/9/10
Re: Interesting article? What do you think? bulldog2 5/9/10
Re: Interesting article? What do you think? » bulldog2 ed_uk2010 5/9/10
Re: Interesting article? What do you think? » ed_uk2010 bulldog2 5/9/10
Re: Interesting article? What do you think? Phillipa 5/9/10
Re: Interesting article? What do you think? desolationrower 5/9/10
Re: Interesting article? What do you think? » Laney conundrum 5/9/10
Re: Interesting article? What do you think? » conundrum 49er 5/10/10
Re: Interesting article? What do you think? SLS 5/10/10
Re: Interesting article? What do you think? » conundrum bulldog2 5/10/10
Re: Interesting article? What do you think? bulldog2 5/10/10
Re: Interesting article? What do you think? Laney 5/10/10
Re: Interesting article? What do you think? » SLS 49er 5/10/10
Re: Interesting article? What do you think? 49er 5/10/10
Re: Interesting article? What do you think? bulldog2 5/10/10
Re: Interesting article? What do you think? SLS 5/10/10
Re: double double quotes » 49er Dr. Bob 5/11/10
Re: Interesting article? What do you think? » bulldog2 Iansf 5/11/10
Re: Interesting article? What do you think? » Iansf bulldog2 5/11/10
Re: Interesting article? What do you think? » 49er SLS 5/12/10
Re: History of depression - um? » 49er linkadge 5/15/10
Re: History of depression - um? » linkadge ed_uk2010 5/15/10
Re: History of depression - um? hansi555 5/15/10
Re: History of depression - um? » ed_uk2010 sigismund 5/15/10
Re: History of depression - um? » sigismund ed_uk2010 5/15/10
...
Re: History of depression - um? Phillipa 5/23/10

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