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Re: What does it mean if a drug has an 'affinity'?

Posted by viper1431 on February 3, 2010, at 22:58:22

In reply to Re: What does it mean if a drug has an 'affinity'?, posted by willey on February 3, 2010, at 22:06:43

It can mean either increase or decrease i think. Affinity just means attraction, so it depends exactly what substance is being talked about. For eg a dopamine antagonist with an affinity for d2 receptors will be attracted to and block d2 receptors, such as antipsychotics.

Where as a dopamine agonist with an affinity for d2 will bind to d2 and effectivly increase it (or so the brain is fooled into thinking), such as the case in parkison drugs.


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URL: http://www.dr-bob.org/babble/20100122/msgs/935913.html