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What does it mean if a drug has an 'affinity'?

Posted by Walfredo on February 3, 2010, at 15:10:04

As in, an "affinity" for a certain receptor? Does that mean it binds to that receptor? If so, what does binding to the receptor result in - a net increase or decrease effect that neurotransmitter's action?

For instance, I read where paroxetine has a weak affinity for the muscarinic acetylcholine receptors. If true, what affect then does this have on acetylcholine? Does it decrease or increase its effect?

I'm kind of assuming it decreases the effect because I know paroxetine is supposedly anticholinergic but would like some confirmation/explanation if some of you guys could maybe explain it better?

Thanks in advance,

Alex

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poster:Walfredo thread:935856
URL: http://www.dr-bob.org/babble/20100122/msgs/935856.html