Posted by willey on January 3, 2010, at 3:37:14
Few things i want to inclide in this post,first i want to mention a med called CAMPREL,although oddly it is soley inicated for alcholoism i still found its pharmocology to be exciting.
It treats neuro toxxicty by its effect of modulating,keeping a balance of glutamte-gaba.
And thats it lol,no deeper action,clean and direct.My view was how can this not be a benifit to psych meds.I did see in japan they use it for all mental disorders.
Anyone being on it two weeks now,i have been told im much better,im 89 percent more pro social,depression seems to have lost its ability to stick,and im very calm.
The change was so dramatic my friend took it as well,she did so because its data sheet states the drug has about ZERO INTERACTIONS,as well as achlol having no effect on its action,nor sedatives,and vice versa.
Here is a snip
"The mechanism of action of acamprosate in maintenance of alcohol abstinence is not completely understood. Chronic alcohol exposure is hypothesized to alter the normal balance between neuronal excitation and inhibition. In vitro and in vivo studies in animals have provided evidence to suggest acamprosate may interact with glutamate and GABA neurotransmitter systems centrally, and has led to the hypothesis that acamprosate restores this balance"
Here is the source
http://www.healthyplace.com/other-info/psychiatric-medications/campral-acamprosate-calcium-full-prescribing-information/menu-id-122/Next id like to mention a drug just released,it is in a class called,NONBENZOS,they call it this because they act on the same sites as standered benzos,but produce ZERO sedation as well as higher anti anxiety effects.There is a whole class on its way out,the first to be released just a week ago was PROGABIDE,however non of them are u.s based.
Here is a snip,
"Gabren - General Information:
Gabren is an analog and prodrug of gamma-aminobutyric acid. It is commonly used in the treatment of epilepsy. It has agonistic activity for both the GABAA and GABAB receptors. Gabren has been investigated for many diseases besides epilepsy, including Parkinson's disease, schizophrenia, clinical depression and anxiety disorder with varying success"source http://www.flexyx.com/G/Gabren.html
PHENIBUT
snip,
"Beta-phenyl-gamma-aminobutyric acid, better known as Phenibut or less commonly Fenibut or Phenybut, is natural derivative of the inhibitory neurotransmitter GABA (Gamma amino butyric acid). Sold as a dietary supplement in the US while in Russia sold as a neuropsychotropic drug that is capable of passing the blood-brain barrier. Phenibut is cited as a nootropic for its ability to improve neurological functions. It was discovered in Russia in the 1960s, and has since been used there to treat a wide range of ailments including anxiety and insomnia.
The name Phenibut, along with many of the other names for the compound, comes directly from the chemical name for the compound, beta-phenyl-gamma-aminobutyric acid."
Source
http://en.wikipedia.org/wiki/Phenibut
poster:willey
thread:932260
URL: http://www.dr-bob.org/babble/20091227/msgs/932260.html