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Re: Parnate losing effectiveness. Why?? Help pleas » metafunj

Posted by Girlnterrupted78 on November 5, 2009, at 19:41:18

In reply to Re: Parnate losing effectiveness. Why?? Help pleas » Girlnterrupted78, posted by metafunj on November 2, 2009, at 23:34:23

> It does sound slightly hypomanic but not manic.

I never thought that could be hypomanic! So many normal people without depression act this way. It just seemed to me that the depression was removed completely and I was able to be myself, my normal self. Or like my doctor, maybe you think I had it "too good". Anyway, this is what I wrote in the very first post when my medication began to work:

On September 14 I wrote:

*Parnate 60mgs helping with social anxiety, finally* --- (http://www.dr-bob.org/babble/20090912/msgs/917009.html)

"Just wanted to let you know the improvement I've had so far with Parnate.
This is just my 1st month on Parnate, and last week was my first week on 60mgs, in addition to 10mgs of Adderall--which were added just a week earlier.
My depression began to improve gradually within the first two weeks. All the ruminations, gut wrenching guilt, chronic emotional distress, etc, began to slowly become less and less intense to the point I was able to feel some peace again.

This past week I was finally allowed to raise my dose to 60mgs, and by the 2nd day on it I finally began to feel comfortable socially.

I don't feel anxious or awkward anymore. I can chat with people, I can laugh and joke. I'm not a social animal by any means; I'm not there yet, but I did get a comment from a friend, who said: "You definitely seem more chatty and engaged than 3 weeks ago." This week I was able to smoothly and easily handle certain people I was incredibly uncomfortable with just 2 weeks earlier.
I'm also able to smile without forcing it and communicate difficult feelings without terrible emotional distress, guilt, or visible internal struggle.
I also had a phone conversation with one of my siblings, one who usually dominates the conversation. I dominated this time, and surprisingly, my vocabulary is returning to my memory. It's been gone for a long time, more than 2 years probably, ever since my dreadful encounter with Nardil. Seems to be back now, I feel so more fluent.
So I'm feeling good, feeling good. Parnate is doing a great job. I feel more confident, more social and more assertive.
The only strange side effect I began to experience upon raising the dose to 60mgs is that about 1-2 hours after each dose, especially the 2nd dose (each dose is 30mgs Parnate+ 5mgs Adderall) my head begins to feel very hot, my face begins to blush, I begin to feel very sleepy and my eyes start to close and I feel very tired and heavy. Not a bad or painful feeling at all, just a bit strange. Something I can live with, but I was just curious if anyone knows what that might be. Thanks"

Most definitely hypomania, right? I was "too good" and should have just been maybe a little more subdued and more uncomfortable to ensure I didn't reach that dreadful hypomanic state of feeling comfortable and confident. You and my doctor would probably be best friends.

> I think you have built a tolerance to Parnate. The way you sound seems similar to someone who has built a tolerance to a drug of abuse and feels tired and flat without increasingly higher dosages.

Could you build tolerance to a medication in just 1 month? That's so little time..

> Also it sounds like you have crashed from the hyperactivity. The pendulum swings both ways and perhaps your body is asking for some rest. Maybe when you feel exhausted the best thing to do is sleep and let your brain restore is balance. I read that parnate totally fragments sleep.

No, I don't think I crashed. I've read that exhaustion is a side effect of Parnate. But hell, yeah, that horrible hypomania I had for a month must be causing this crash now.


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poster:Girlnterrupted78 thread:923267
URL: http://www.dr-bob.org/babble/20091029/msgs/924651.html