Posted by bleauberry on September 11, 2009, at 17:34:08
In reply to Parnate dosage/no wonder, posted by willyeee on September 11, 2009, at 12:03:33
Scott is correct. Within that short 2.5 hours, Parnate permanently shuts down MAO enzymes. They don't come back. Never will. The same enzymes that were shut down by Parnate in that 2.5 hours are still shut down 24 hours later, 48 hours later, even 72 hours later. We have to wait for new enzymes to be produced to replace them, which takes days. So even though Parnate is in and out real fast, the changes it made are longlasting, long past the time the drug itself is totally gone.
There are other mechanisms of Parnate not well understood. My guess is they are probably more directly related to dosage frequency and dosage halflives.
poster:bleauberry
thread:916492
URL: http://www.dr-bob.org/babble/20090902/msgs/916537.html