Posted by SLS on September 11, 2009, at 12:43:18
In reply to Parnate dosage/no wonder, posted by willyeee on September 11, 2009, at 12:03:33
> I have read the numerous threads on parnate,i agree with scott,...and for people who dont feel well with the idea of HIGH PARNATE DOSES,....one thing you should know is PARNATES HALF LIFE IS 2.5 HOURS !!!!! My god almost feel off chair when i read that,that is a very very short time for a drug to be active.
I would just add that Parnate goes in, does its work, and then disappears within that 2.5 hours. That work is permanent, though. The MAO enzymes that it attaches to are disabled. It takes days before enough new MAO enzymes are produced to replace the old disabled ones.
Parnate has been shown to produce changes in neurotransmitter receptors at very high dosages (120+ mg) that it does not at lower dosages. These things do not depend on 100% MAO inhibition, as this percentage is obtained at lower dosages (60-80mg). This includes the downregulation of 5-HT2 serotonin receptors.
- Scott
poster:SLS
thread:916492
URL: http://www.dr-bob.org/babble/20090902/msgs/916498.html