Posted by bulldog2 on August 16, 2009, at 12:42:49
In reply to Re: To SLS, Parnate Question, posted by g_g_g_unit on August 15, 2009, at 22:07:44
> > Parnate is somewhat selective for MAO-B, which is responsible for deaminating (splitting up) dopamine. The effect of Parnate, then, is to allow for a build up and subsequent release of dopamine. It also works to increase levels of phenethylamine (PEA), a neuromodulator, as well. PEA can increase the levels of dopamine in frontal regions of the brain. Parnate itself acts as an amphetamine, but only at 10% the potency of d-amphetamine. There are some old studies reporting the efficacy of Parnate in treating ADD. There is no reason why one could not combine Parnate with amphetamine or methylphenidate to treat depression comorbid with ADD.
> >
> >
> > - Scott
>
> unfortunately, since i do not have ADD (only depression-related symptoms), stimulants are strictly prohibited from being prescribed where i live. i've only managed to try ritalin through a friend.. hence my interest in parnate, since it may be the closest thing to a stimulant i can presently get my hands on, bar wellbutrin, which just increases my anxietyyou have to understand the stimulant effect only lasts about two hours max or at least only for me.After that felt pretty calm or at times a bit sleepy.
I think my disappointment with parnate was I thought I was going to be activated most of the time which for me wasn't the case.Now drugs that strictly block the reuptake of norepinephrine should be safe with parnate such as nortriptyline and possibly ritalin.
On the other hand amphetamines that release norepinephrine should be used with caution as that could trigger a hypertensive crisis.
poster:bulldog2
thread:912141
URL: http://www.dr-bob.org/babble/20090810/msgs/912417.html