Posted by SLS on August 15, 2009, at 17:43:05
In reply to Re: To SLS, Parnate Question, posted by shasling on August 15, 2009, at 15:05:41
> Heres the link,at least its a reputable one,
> http://74.125.155.132/search?q=cache:ENhlwhJ3wewJ:www.biopsychiatry.com/tranylcypromine-parnate.htm+parnate+gaba+b&cd=1&hl=en&ct=clnk&gl=us
>
> Linkadge said something to the affect this doesent mean anything,however to my knowledge
> substances affecting gaba b are
>
> Alcholol
> GHB
> Phenibut
> Bacoflen> Also gaba b is usualy the one that unlike benzos and gaba A which work on anxiety,gaba B is more like a social effect and less anti anxiety.
I didn't realize that. Thanks for the explanation.
> Perhaps this contributes to parnates pro social effect.
You might be right. I would like to know through what mechanism GABA-B receptors become upregulated.
I'm thinking that there might also be an increase in phenethylamine in the brain that would lead to an inhibition of the GABA-B receptor, thus disinhibiting (increasing) dopaminergic neurotransmission. I don't know. There has long been a "rumor" that Parnate is metabolized into amphetamine or amphetamine-like substances. I don't think any have been isolated, though. It seems more likely that the parent molecule has amphetamine-like actions of its own.
- Scott
poster:SLS
thread:912141
URL: http://www.dr-bob.org/babble/20090810/msgs/912291.html