Posted by doxogenic boy on August 15, 2009, at 15:59:40
In reply to Re: hydromorphone in combination with six other meds » doxogenic boy, posted by SLS on August 15, 2009, at 9:30:53
> Hi.
>
> The addition of memantine (Namenda) can help
> prevent the development of tolerance to the
> analgesic effects of opioids.Thank you, I will take this with me to my psychiatrist.
Ultralow doses of naltrexone has been considered for me, but it will probably be both expensive and difficult to obtain, my psychiatrist said. I wonder how those who have tried naltrexone in about 0,5 mcg (microgram) doses, have got it? I asked the pharmacy at the local hospital if they could thin 50 mg naltrexone tablets to 0,5 mcg, but they said they did not have the equipment for this, or that it was "impossible" to thin naltrexone 100 000 times.
About naltrexone:
http://www.ncbi.nlm.nih.gov/pubmed/16681181Excerpt from url:
"Concomitant administration of minute doses (about 0.5 mcg) of the opioid antagonist naltrexone with each dose of codeine was found in both cases to obviate the expected opioid withdrawal syndrome, resulting in asymptomatic and uneventful transitions from physical opioid dependency states to exogenous opioid-free metabolism.
[...]
It was found that coadministration of naltrexone with codeine phosphate obviated the development of both tolerance and physical dependency over several months of four daily oral doses of 200 mg, allowing abrupt ("cold turkey"), asymptomatic and uneventful withdrawal."> Hopefully, it
> would also work this way for the psychotropic > effects of these drugs. However, data is
> lacking.Yes, I find it strange that the amazing effects of opioids on serverly treatment-resistant depression in some cases in the scientific literature haven't been followed with enthusiastic research for how to stop tolerance buildup against the antidepressant effect of opioids.
There are no promising antidepressants in the pipeline the nearest years, so what can we do in the meantime?
> Does the trimipramine make for a good sleep
> aid? What about anxiety?Trimipramine make me extremely sedated the first night, and I can sleep for up to twenty hours (not continuosly, though) but this effect fade away more or less after a short time.
I have always had problems with sleep (insomnia and periodic limb movements during sleep), but this combination of medicines actually have made it easy to fall asleep and stay asleep both for an after-dinner nap and during the night. I manage to sleep in the night even though I have slept two hours in the afternoon.
I suppose this is because of trimipramine, quetiapine, clonazepam and now also hydromorphone. But too much sleep is said to be depressogenic...
Clonazepam and hydromorphone probably works against the periodic limb movements during sleep.
Lots of psychotropics worsen that sleep disorder.The reason why I asked for trimipramine, was its anxiolytic properties and to suppress anxiety from escitalopram. I can't say for sure if it actually had that effect, but I haven't dared to try without if it could cause the anxiety and insomnia to come back.
doxogenic
poster:doxogenic boy
thread:912227
URL: http://www.dr-bob.org/babble/20090810/msgs/912275.html