Posted by SLS on June 2, 2009, at 15:38:36
In reply to I feel like I'm taking Clomipramine, Why??, posted by ricker on June 2, 2009, at 14:18:43
> I was on clomipramine - 150mg for 10 years in the 90's. It worked graet but my p/doc switched to see if some side-effect would disappear which they did.
>
> With my current cocktail, zoloft 50mg, lamictal 100mg and zyprexa 5mg, I feel like I did when I was on the clomipramine...less the side-effects?
>
> Any of you chemical experts have an opinion as to why? Would my current combination hit the neros in a similar fashion?
>
> Thanks, Rick
Hi Rick.I truly am no expert. You would know that if you were to read just a handful of abstracts coming from the NLM Medline (Pubmed).
Anyway, one thing that the treatments have in common is that both clomipramine and Zoloft are potent reuptake inhibitors of serotonin (5-HT). As for the other two drugs, I really can't say how they might help, if at all. For my bipolar depression, Lamictal does help partially and consistenly. It is often used by others as an antidepressant. Zyprexa helped me partially and transiently. It is often used in combination with Prozac, an SSRI like Zoloft to produce an antidepressant response. So there is undoubtedly an antidepressant potential to all three drugs that you are taking.
The two things lacking in you new treatment regime that you had in your old one is norepinephrine (NE) reuptake inhibition and anticholinergic effects. This is probably why you are experiencing fewer side effects.
- Scott
poster:SLS
thread:899041
URL: http://www.dr-bob.org/babble/20090531/msgs/899055.html