Posted by SLS on May 5, 2009, at 5:56:35
In reply to Re: Why after increasing the dose? SLS-Anybody pls » tepi, posted by jedi on May 5, 2009, at 3:45:56
> IMHO any benefit from any mainstream antidepressant during the first day is a placebo effect.
You would think so, but these drugs are extremely powerful, and strange things can occur upon the initial exposure to them or upon dosage adjustments.
You are right that the true antidepressant response occurs latent to the initiation of treatment. It is hypothesized that it is not the acute effects of the drug that is the response, but, rather, the changes that occur in the brain as a reaction to chronic exposure. It just so happens that the turnover rate for receptors is about two weeks. If you figure in the delay that probably exists for changes in gene activity, you might be looking at three weeks.
I can attest personally to the biological origin of the type of blip response that Tepi experienced. It has happened with me with several drugs, including Effexor. The improvement I experienced after taking my very first dose of Effexor lasted for several hours. After that, I did not see an improvement for another 2-3 weeks. I believe that Nardil can produce a similar acute reaction for exactly those reasons you cite below:
- Scott> I qualified my last statement with "mainstream" because sometimes the stimulants and other medications that affect dopamine can give almost immediate relief. I really have never seen these medications work long term for a person. Also, some of the narcotic medications can give very quick relief. Again, I suspect that very few people have been given long term relief from depression with narcotics. And do not mix stimulants or narcotics with Nardil; unless you know exactly and precisely what you are doing.
> Wishing you the Best,
> Jedi
>
>
poster:SLS
thread:894304
URL: http://www.dr-bob.org/babble/20090505/msgs/894324.html